Part 1.Transpeptidation and Isomerization.
The Role of Protein L-Isoaspartyl/D-Aspartyl-Aspartyl O-Methyl-transferase
(PIMT) in Interacellar Signal Transduction (T. Furuchi K. Sakurako, M.
Katane, M. Sekine, H. Homma).
Modeling the Enolization of Succinimide Derivatives, a Key Step of
Raceminization of Aspartic Acid Residues: Importance of a Two-H2O Mechanism
(O. Takahashi, K. Kobayashi, A. Oda).
Molecular-Dynamics Simulations for Amyloid ß1-42 Monomer with
D-Aspartic Acid Residues Using Continuous Solvent (A. Oda, K. Kobayashi , O.
Takashashi).
Accumulation of D-ß-Aspartic Acid-Containing Proteins in Age-Related
Ocular Diseases (Y. Kaji, T. Oshika Y. Takazawa, M. Fukayama, N. Fujii).
Quantification of Structural Alterations of L-Asp and L-Asn Residues in
Peptides Related to Neuronal Diseases by Reversed –Phase high Performance
Liquid Chromatography (Y. Sadakane, K. Konoha, M. Jawahara, K. Nakagomi).
SAXS and SANS Observations of Abnormal Aggregation of Human a-Crystallin
(M. Sugiyama, N. Fujii, Y. Morimoto, K. Itoh, K. Mori, T. Fukunaga, N. Fujii).
Collapse of Homochirality of Amino Acids in Proteins from Various Tissues
during Aging (N. Fujii, Y. Kaji, N. Fujii, T. Nakamura, R. Motoie, Y. Mori,
T. Kinouchi).
Influence of Oxidative Stress on D-Aspartyl Endopeptidase Activity (T.
Kiniuchi, A. Matsuda, S. Kawakami, T. Shimizu, T. Shirasawa, N. Fujii).
Structural Consideration of Mammalian D-Aspartyl Endopeptidase (T.
Kinouchi, N. Fujii).
Oxidative Stress Induces the Formation of D-Aspartyl Residues in the
Elastin Mimic Peptides (K. Kuge, K. Kitamura, K. Nakaoji, K. Hamada, N.
Fujii, T. Saito, N. Fujii).
Part 2. D-Amino Acid (D-Aspartic Acid) Oxidase.
Indispensable but Insufficient Role of Renal D-Amino Acid Oxidase in
Chiral Inversion of NG-Nitro D-arginine (Y.F. Xin, X. Li, B. Hao,
N. Gong, W.-Q. Sun, R. Konno, Y.-X. Wang).
Comparative Characterization of Three D-Aspartate Oxidases and One
D-Amino Acid Oxidase from Caeno-rhabditis elegans (M. Katane, Y. Saitoh, Y.
Seida, M. Sekine, T. Furuchi, H. Homma).
D—Aspartate Oxidase: The Sole Catabolic Enzymes Acting on Free D-Aspartate
in Mammals (M. Katane, H. Homma).
Mutant Mice and Rats Lacking D-Amino Acid Oxidase R. Konno, K. Hamase, R.
Maruyama, K. Zaitsu).
Effects of D-Aspartate Treatment on D-Aspartate Oxidase, Suoeroxide
Dismutase , and Capase 3 Activities in Frog (Rana esculenta) Tissues (L.
Buroone, M. Di Giovanni, M. M. Di Fiore, G. C. Baccari, A. Santillo).
Thyroid Hormones and D-Aspartic Acid, D-Aspartate Oxidase, D-Aspartate
Racemase, H2O2 and ROS in Rats and Mice (E. Topo, G.
Fisher, A. Sorricelli, F. Errico, A. Usiello, A. D. Aniello).
Aberrant Control of Motoneuronal Excitability in Amyotrophic Lateral
Sclerosis: Excitatory Glutamate/D Serine vs. Inhibitrory Glycine/?-Aminobutanoic
Acid (GABA).
Part 3. D-Amino Acids Related to Nutrition and Industrial Applications.
Origin, Microbiology, Nutrition, and Pharmacology of D-Amino Acids (M.
Friedman).
Natural Occurrence and Industrial Applications of D-Amino Acids: An
Overview (S. Martínez-Rodríquez, A. I. Martínez-Gómez, F. Rodríguez-Vico, J.
M. Clemente-Jiménez, F. J. Las Heras-Vázquez).
Enzymes Responsible for the Conversion of Na-[(Benzyloxy)
carbonyl]-D-Lysine to Na-[Benzyloxy)-carbonyl]-D-aminoadipic Acid
by Rhodococcus sp. AIU Z-35-1 (K. Isobe, N. Fukuda, S. Nagasawa, K. Saitou).
New Biological Functions and Applications of High –Molecular-Mass Poly-?-glutamic
Acid (H. Poo, C. Park. M.-S. Kwak, D,-Y. Choi, S.-P. Hong, I.-H. Lee, Y. T.
Lim, Y. K. Choi, S.-R. Bae, H. Uyama, C.-J. Kim, M.-H. Sung).
Identification and Biochemical Chartacterization of Membranous
Short-Chain Polyglutamate from Bacillus subtilis (T. Kamei, D, Yamashiro, T.
Horiuchii, Y. Minouchi, M. Ashiuchi).
Part 4. Amino Acid Racemases and Peptide Isomerases.
Serine Racemase Knockout Mice (H. Mori, R. Inoue).
Site-Directed Mutagenesis of Rice Serine Racemase: Evidence That Glu219
and Asp225 Mediate the Effects if Mg2+ on the Acitivity (Y.
Gogami, A. Kobayashi, T. Ikeuchi, T. Oikawa).
Detection and Function of the Intramolecular Disulfide Bond in Arginine
Racemase: An Enzyme with Broad Substrate Specificity (D. Matsui, T. Oikawa).
Mammalian Peptide Isomerase: Platypus-Type Activity Is Present in Mouse
Heart (J. M. S. Koh, S. J. P. Chow, B. Crossett, P. W. Kuchel).
Part 5. Racemization Mechanisms and Chemistry of D-Amino Acids.
Configurational Assignment of D- and L- Isovalines in Intact, Natural,
and Synthetic Peptides by 2D-NMR Spectroscopy (M. De Zotti, E. Schievano, S.
Manni, B. Kaptein, Q.B. Broxterman, S. B. Singhm H. Brückner, C. Toniolo).
Computational Insight into the Mechanism of Serine Residue Racemization
(O. Takahashi, K. Kobayashi, A. Oda).
Computational Modeling of the Enolization in a Direct Mechanism of
Racemization of the Aspartic Acid Residue (O. Takahashi, K. Kabayashi, A.
Oda).
Protein-Engineering Study of Contribution of Conceivable D-Serine
Residues to the Thermostabilization of Ovalbumin under Alkaline Conditions
(N. Takashashi, M. Maeda, M. Yamasaki B. Mikami).
Generation of Enantiomeric Amino Acids during Acid Hydrolysis of Peptides
Detected by the Liquid Chromatogaphy/Tandem Mass Spectroscopy (T. Miyamoto,
M. Sekine, T. Ogawa, M. Hidaka, H. Homma, H. Masaki).
Photolysis of rac-Leucine with Circularly Polarized Synchrotron Radiation
(U. J. Meierhenrich, J.-J. Filippi, C Meinert, S. V. Hoffmann, J. H.
Bredehöft, L. Nahon).
Amino Acid Ligand Chirality for Enantioselective Synthees (K. Mucskei, T.
Patonary, L. Caglioti, G. Pályi).
Hydrophobicity of Peptides Containing D-Amino Acids (T. Munegumi).
Index.
Hans Brückner
and Noriko Fujii (Eds.)