D-Amino Acids
Back Home Up Next


Hans Brückner and Noriko Fujii (Eds.)

D-Amino Acids
in Chemistry, Life Sciences, and Biotechnology






Order Now!

ISBN-10: 3-906390-65-9
ISBN-13: 978-3-90639-065-9

392 pages
December 2010


D-Amino Acids in Chemistry, Life Sciences and Biotechnology presents a collection of state of the art contributions from leading scientists in D-amino acid research, a field that has significant implications in relation to health care, research in age-related and neuronal diseases, pharmaceutical chemistry and food science.

The increasing importance of D-amino acids and the need for a forum to exchange ideas and hypothesis led to the foundation of the 'D-Amino Acid Research Society' in Japan, followed by the First International Conference on D-Amino Acid Research in 2009. The majority of the contributions published in D-Amino Acids in Chemistry, Life Sciences and Biotechnology result from this event and reflect the long-standing interest of the Guest Editors and their co-workers and collaborators in the field of D-amino acid research.


Part 1.Transpeptidation and Isomerization.

The Role of Protein L-Isoaspartyl/D-Aspartyl-Aspartyl O-Methyl-transferase (PIMT) in Interacellar Signal Transduction (T. Furuchi K. Sakurako, M. Katane, M.  Sekine, H. Homma).

Modeling the Enolization of Succinimide Derivatives, a Key Step of Raceminization of Aspartic Acid Residues: Importance of a Two-H2O Mechanism (O. Takahashi, K. Kobayashi, A. Oda).

Molecular-Dynamics Simulations for Amyloid ß1-42 Monomer with D-Aspartic Acid Residues Using Continuous Solvent (A. Oda, K. Kobayashi , O. Takashashi).


Accumulation of D-ß-Aspartic Acid-Containing Proteins in Age-Related Ocular Diseases (Y.  Kaji, T. Oshika Y. Takazawa, M. Fukayama, N. Fujii).

Quantification of Structural Alterations of L-Asp and L-Asn Residues in Peptides Related to Neuronal Diseases by Reversed –Phase high Performance Liquid Chromatography (Y. Sadakane, K. Konoha, M. Jawahara, K. Nakagomi).

SAXS and SANS Observations of Abnormal Aggregation of Human a-Crystallin (M. Sugiyama, N. Fujii, Y. Morimoto, K. Itoh, K. Mori, T. Fukunaga, N. Fujii).

Collapse of Homochirality of Amino Acids in Proteins from Various Tissues during Aging (N. Fujii, Y. Kaji, N. Fujii, T. Nakamura, R. Motoie, Y. Mori, T. Kinouchi).

Influence of Oxidative Stress on D-Aspartyl Endopeptidase Activity (T. Kiniuchi, A. Matsuda, S. Kawakami, T. Shimizu, T. Shirasawa, N. Fujii).

Structural Consideration of Mammalian D-Aspartyl Endopeptidase (T. Kinouchi, N. Fujii).

Oxidative Stress Induces the Formation of D-Aspartyl Residues in the Elastin Mimic Peptides (K. Kuge, K. Kitamura, K. Nakaoji, K. Hamada, N. Fujii, T. Saito, N. Fujii).

Part 2. D-Amino Acid (D-Aspartic Acid) Oxidase.

Indispensable but Insufficient Role of Renal D-Amino Acid Oxidase in Chiral Inversion of NG-Nitro D-arginine (Y.F. Xin, X. Li, B. Hao, N. Gong, W.-Q. Sun, R. Konno, Y.-X. Wang).

Comparative Characterization of Three D-Aspartate Oxidases and One D-Amino Acid Oxidase from Caeno-rhabditis elegans (M. Katane, Y. Saitoh, Y. Seida, M. Sekine, T. Furuchi, H. Homma).

D—Aspartate Oxidase: The Sole Catabolic Enzymes Acting on Free D-Aspartate in Mammals (M. Katane, H. Homma).

Mutant Mice and Rats Lacking D-Amino Acid Oxidase R. Konno, K. Hamase, R. Maruyama, K. Zaitsu).

Effects of D-Aspartate Treatment on D-Aspartate Oxidase, Suoeroxide Dismutase , and Capase 3 Activities in Frog (Rana esculenta) Tissues (L. Buroone, M. Di Giovanni, M. M. Di Fiore, G. C. Baccari, A. Santillo).

Thyroid Hormones and D-Aspartic Acid, D-Aspartate Oxidase, D-Aspartate Racemase, H2O2 and ROS in Rats and Mice (E. Topo, G. Fisher, A. Sorricelli, F. Errico, A. Usiello, A. D. Aniello).

Aberrant Control of Motoneuronal Excitability in Amyotrophic Lateral Sclerosis: Excitatory Glutamate/D Serine vs. Inhibitrory Glycine/?-Aminobutanoic Acid (GABA).

Part 3. D-Amino Acids Related to Nutrition and Industrial Applications.

Origin, Microbiology, Nutrition, and Pharmacology of D-Amino Acids (M. Friedman).

Natural Occurrence and Industrial Applications of D-Amino Acids: An Overview (S. Martínez-Rodríquez, A. I. Martínez-Gómez, F. Rodríguez-Vico, J. M. Clemente-Jiménez, F. J. Las Heras-Vázquez).

Enzymes Responsible for the Conversion of Na-[(Benzyloxy) carbonyl]-D-Lysine to Na-[Benzyloxy)-carbonyl]-D-aminoadipic Acid by Rhodococcus sp. AIU Z-35-1 (K. Isobe, N. Fukuda, S. Nagasawa, K. Saitou).

New Biological Functions and Applications of High –Molecular-Mass Poly-?-glutamic Acid (H. Poo, C. Park. M.-S. Kwak, D,-Y. Choi, S.-P. Hong, I.-H. Lee, Y. T. Lim, Y. K. Choi, S.-R. Bae, H. Uyama, C.-J. Kim, M.-H. Sung).

Identification and Biochemical Chartacterization of Membranous Short-Chain Polyglutamate from Bacillus subtilis (T. Kamei, D, Yamashiro, T. Horiuchii, Y. Minouchi, M. Ashiuchi).

Part 4. Amino Acid Racemases and Peptide Isomerases.

Serine Racemase Knockout Mice (H. Mori, R. Inoue).

Site-Directed Mutagenesis of Rice Serine Racemase: Evidence That Glu219 and Asp225 Mediate the Effects if Mg2+ on the Acitivity (Y. Gogami, A. Kobayashi, T. Ikeuchi, T. Oikawa).

Detection and Function of the Intramolecular Disulfide Bond in Arginine Racemase: An Enzyme with Broad Substrate Specificity (D. Matsui, T. Oikawa).

Mammalian Peptide Isomerase: Platypus-Type Activity Is Present in Mouse Heart (J. M. S. Koh, S. J. P. Chow, B. Crossett, P. W. Kuchel).

Part 5. Racemization Mechanisms and Chemistry of D-Amino Acids.

Configurational Assignment of D- and L- Isovalines in Intact, Natural, and Synthetic Peptides by 2D-NMR Spectroscopy (M. De Zotti, E. Schievano, S. Manni, B. Kaptein, Q.B. Broxterman, S. B. Singhm H. Brückner, C. Toniolo).

Computational Insight into the Mechanism of Serine Residue Racemization (O. Takahashi, K. Kobayashi, A. Oda).

Computational Modeling of the Enolization in a Direct Mechanism of Racemization of the Aspartic Acid Residue (O. Takahashi, K. Kabayashi, A. Oda).

Protein-Engineering Study of Contribution of Conceivable D-Serine Residues to the Thermostabilization of Ovalbumin under Alkaline Conditions (N. Takashashi, M. Maeda, M. Yamasaki B. Mikami).

Generation of Enantiomeric Amino Acids during Acid Hydrolysis of Peptides Detected by the Liquid Chromatogaphy/Tandem Mass Spectroscopy (T. Miyamoto, M. Sekine, T. Ogawa, M. Hidaka, H. Homma, H. Masaki).

Photolysis of rac-Leucine with Circularly Polarized Synchrotron Radiation (U. J. Meierhenrich, J.-J. Filippi, C Meinert, S. V. Hoffmann, J. H. Bredehöft, L. Nahon).

Amino Acid Ligand Chirality for Enantioselective Synthees (K. Mucskei, T. Patonary, L. Caglioti, G. Pályi).

Hydrophobicity of Peptides Containing D-Amino Acids (T. Munegumi).