P. Heinrich Stahl, Camille G. Wermuth (Eds.)
Handbook of Pharmaceutical Salts: Properties, Selection, and Use
Second, Revised Edition
The first edition of this handbook was a tremendous success,
collating the scientific literature on this topic that had otherwise been rather
limited and scattered throughout numerous journals and patents. The result was a
comprehensive resource that addresses the preparation, selection, and use of
pharmaceutically active salts, examining the opportunities for increased
efficacy and improved drug delivery provided by the selection of an optimal salt.
This second, revised edition is designed to meet the continued interest in both
the topic and the book.
IndexIntroduction (Camille G. Wermuth and P. Heinrich Stahl).
Chapter 1. The Physicochemical Background: Fundamentals of Ionic Equilibria (Michael B. Maurin, David J. W. Grant, and P. Heinrich Stahl).
Chapter 2. Solubility and Dissolution of Weak Acids, Bases, and Salts (Madhu Pudipeddi, Abu T. M. Serajuddin, David J. W. Grant, and P. Heinrich Stahl).
Chapter 3. Evaluation of Solid-State Properties of Salts (Danielle Giron and David J. W. Grant).
Chapter 4. Pharmaceutical Aspects of the API Salt Form (P. Heinrich Stahl and Finlay S. Skinner).
Chapter 5. Biological Effects of the API Salt Form (Friedlieb Pfannkuch, Harald Rettig, and P. Heinrich Stahl).
Chapter 6. Salt-Selection Strategies (Abu T. M. Serajuddin and Madhu Pudipeddi).
Chapter 7. A Procedure for Salt Selection and Optimization (Michael J. Bowker).
Chapter 8. High-Throughput Strategies and Techniques for Salt Screening (Nicole Wyttenbach, Bertrand Sutter, and Pirmin Hidber).
Chapter 9. Large-Scale Aspects of API Salt Manufacture (Piotr H. Karpiński).
Chapter 10. Patent Aspects of API Salt Formation (Hans-GŁnther Foraita).
Chapter 11. Regulatory Aspects of API Salts (Maria Arfwedson and Alan Chalmers, Jun-ichi Kondo and P. Heinrich Stahl, and Mansoor A. Khan and Vilayat A. Sayeed).
Chapter 12. Selected Procedures for the Preparation of Pharmaceutically Acceptable Salts (Camille G. Wermuth and P. Heinrich Stahl).
Chapter 13. Monographs on Acids and Bases (P. Heinrich Stahl and Camille G. Wermuth).
Appendix (P. Heinrich Stahl).
"...It should be in the library of every pharmaceutical company...It fills a vital gap in the literature..." (Organic Process Research & Development Journal)
"...the editors have produced a rare commodity, a body of knowledge on an important area, summarized in single volume. In a nutshell, this long-overdue volume belongs on the personal shelf of every pharmaceutical scientist working with new chemical entities." (Pharmaceutical Development and Technology, Vol. 8, No. 3)